Isotype:  Mouse IgG1k

Immunogen:  Recombinant human TIGIT

INFORMATION: Human TIGIT (T cell immunoreceptor with Ig and ITIM domains) is a co inhibitory receptor expressed by activated T cells, memory T cells, Treg cells and NK cells.  It binds to CD155(PVR) and less avidly to CD112(PVRL2). Blockade of the TIGIT/CD155 axis shows promise in restoring T cell function in pancreatic cancer(2).

Specificity: Antibody ANCTG6 binds to receptors on a sub set of  human peripheral blood lymphoid cells, as well as to recombinant TIGIT in EIA.

References:

1)  Dougall WC, AC Anderson, et al. (2017) Immunol Rev 276(1): 112-120. doi: 10.1111/imr.12518 PMID: 28258695

2) Freed-Pastor WA, Tyler Jacks, et al. (July 2021) Cancer Cell S1535-6108(21)00384-6. doi: 10.1016/j.ccell.2021.07.007

USD $275.00

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= $275.00
Catalog #: 340-030
Form: Biotin
Size: 100 µg
Alternate Name: T cell immunoreceptor with Ig and ITIM domains
Clone: ANCTG6/10A6

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