The inducible costimulator CD278 (ICOS, T cell activation molecule H4) is similar to human CD28 (24% homology), and plays an analogous role in the T cell activation process.  Each secondary signal from CD28 or ICOS results in a discrete cytokine secretion profile displayed by the activated T cell.1  Both activation processes are effectively down regulated by CD152 (CTLA-4) engagement.2  Human CD275 (ICOSL, GL50, B7-H2) is a member of the B7 family sharing ~20% homology with CD80 (B7-1) and CD86 (B7-2), and has been shown to be a ligand for CD278.3 CD278-muIg recombinant protein binds to recombinant CD275-muIg in EIA.

Molecular Structure:   A soluble  fusion protein consisting of the extracellular (121aa) domain of mature human CD278(ICOS): eingsanyemfifhnggvqilckypdivqqfkmqllkggqilcdltktkgsgntvsikslkfchsqlsnnsvsfflynldhshanyyfcnlsifdpppfkvtltggylhiyesqlccqlkf

linker amino acids: gt

fused to murine IgG2a Fc (233 aa): eprgptikpcppckcpapnllggpsvfifppkikdvlmislspivtcvvvdvseddpdvqiswfvnnvevhtaqtqthredynstlrvvsalpiqhqdwmsgkefkckvnnkdlpapiertiskpkgsvrapqvyvlpppeeemtkkqvtltcmvtdfmpediyvewtnngktelnykntepvldsdgsyfmysklrvekknwvernsyscsvvheglhnhhttksfsrtpgk

predicted nonglycosylated monomeric molecular weight: 40.4 kd.

Transfectant Cell Line:  CHO

Functional Application:   CD278-muIg binds  to recombinant CD275(ICOSL, GL50)-muIg in EIA.


1Beier, K.C., R.A. Kroczek, et al. 2000, Eur J Immunol. 30(12):3707-3717.

2 Riley, J.L., C.H. June, et al. 2001, J. Immunol. 166: 4943-4948.

3 Ling, V., M. Collins, et al. 2000, J. Immunol. 164: 1653-1657.

4 Ling, V., M. Collins, et al. 2001, J. Immunol. 166: 7300-7308.

5 A.J. McAdam, et al, (2000) J Immunol 165: 5035-5040.

USD $300.00

In cart: 0
= $300.00
Catalog #: 517-020
Form: Pur/WA
Size: 25 µg
Alternate Name: ICOS, AILIM, ICOS-Fc, ICOS-muIg, ICOS-Ig
Applications: FC, EIA


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