CD127 (IL-7Ra) is the specific receptor component for the cytokine Interleukin -7 (IL-7).  It is found on a wide variety of hematopoietic cell types including B cell precursors, and the majority of T cells.  Its expression levels are decreased on T cells following activation.   CD127 can dimerize with CD132(IL-2Rg) to form a high affinity IL-7 receptor (1).  CD127 engagement is necessary for T cell development in humans (2).

Isotype: Murine IgG1 kappa

Immunogen: Recombinant human CD127

Specificity: Antibody ANC8F2 recognizes an extracellular epitope of human recombinant and native CD127 in FACS and Enzyme Immunoassay.

References: 

1)  Noguchi, M. et al., 1993, Science 262:1877.

2)  Pribyl, J.A. and T.W. LeBien, 1996, Proc. Natl. Acad. Sci. 93:10348. 

3)  Goodwin RG, Friend D, Ziegler SF, et al. Cell. 1990;60:941.

USD $275.00

In cart: 0
= $275.00
Catalog #: 348-040
Form: FITC
Size: 120 tests
Alternate Name: IL-7Rα
Clone: ANC8F2
Applications: FC

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