Human CD105 (endoglin) is a homodimeric membrane glycoprotein (1) virtually restricted to endothelial cells, and present on some leukemia cells and minor subsets of bone marrow cells. CD105 binds to TGF-b1 and b3 with high affinity (4).
Isotype: Murine IgG1 kappa
Immunogen: Membrane preparation of human B-lineage leukemia cells
Specificity: Antibody SN6 recognizes an extracellular epitope of the human CD105 homodimer with a molecular weight of about 160 kd. It has been reported to cross react with non human Primate as well as Equine and Porcine(11) CD105.
Functional Application: Antibody SN6 will augment binding of TGF-b1 to CD105 expressing leukemia cells. Antibody SN6 has been used to identify mesenchymal progenitor cells populations (8,9,10).
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12. M Vigano, de Girolamo, et al. (Feb 2017) J Exp Orthopaedics 4: 8.