Human CD18 (beta integrin) forms a heterodimer with either alpha L, alpha M, or alpha X integrins (CD11a, b or c).  CD11/CD18 heterodimeric molecules are involved with cell/cell and cell/extracellular adhesion in immune and inflammatory responses.

Isotype: Murine IgG2a

Immunogen: Human peripheral blood monocytes

Specificity: Antibody IB4 recognizes the beta 2 integrin subunit (CD18) adhesion molecule of about 95 kd (1, 6).

Functional Application: Antibody IB4 blocks binding of ICAM-1 and ICAM-3 to LFA-1 (2, 5).

References:

1.  S.D. Wright, et al, (1983) Proc Natl Acad Sci USA  80: 5699-5703.

2.  R.C. Landis, et al, (1994) J Cell Biol  126: 529-537.

3.  M. Kaneko, et al, (1995) J Immunol  155: 2631-2641.

4.  A. Mazzone & G. Ricevuti, (1995) Haematologica  80: 161-175.

5.  M.E. Berman, et al, (1996) J Immunol 156: 1515-1524.

6.  K Welzenbach, G Weitz-Scmidt, et al (2002) J Biol Chem 277(12): 10590 - 10598. PMID: 11781316

USD $695.00

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= $695.00
Catalog #: 167-580
Form: Fab
Size: 100 µg
Alternate Name: integrinβ 2
Clone: IB4
Applications: FC

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