Human T cell receptor (TCR) is a T cell surface expressed heterodimer of alpha/beta or gamma/delta chains. TCR’s recognize antigen peptides bound to MHC molecules forming the basis of antigen specific response by T cells (3, 4).
Isotype: Murine IgG2a
Immunogen: Human HA1.7 TCR beta chain expressed on transgenic mouse cells
Specificity: Antibody JOVI-1 recognizes human C beta 1 TCR gene product and reacts with 50-75% of T cells in normal human blood (1). JOVI-1 does not bind to TCR C beta 2 (5).
Functional Application: Antibody JOVI-1 is mitogenic for T cells expressing TCR C beta 1. Jovi-1 has been used to ideintify T-cell Leukemia(8), and other T cell malignancies(9).
1. J.L. Viney, et al, (1992) Hybridoma 11: 701-713. PMID: 1284120
2. A. Weiss, (1993) Cell 73: 209-212.
3. M.M. Daris, (1995) Nature 375: 104.
4. S. Valitutti, et al, (1995) Nature 375: 148-151.