ISOTYPE: Mouse IgG1k

INFORMATION: The p75 low affinity human Nerve Growth Factor receptor CD271(NGRF, TNFRSF16) is expressed on a variety of tissue types including a subset of splenic and nodal lymphocytes. Presence of this receptor supports uptake of intracellular calcium, but not mobilization (3). CD271 is a stem cell marker for hematopoietic(5,6,7), stromal (8) as well as cancer cells (9,10).  CD271 has been reported to inhibit differentiation of mesenchymal cells into various lineages(11). 

Antibody ANC271/3D7 binds to recombinant CD271-muIg (cat# 527-020) in EIA, and to endogenous CD271 on cell surface of human Reh cells.

REFERENCES:

1) Brodie C, E W Gelfand (1992) Journal of Immunology. 148(11): 3492-3497.

2) Fantini F, O. Johansson  (1992) Journal of Investigative Dermatology. 99(6): 734-742. 

3) Jiang H, G Gurogg, et al.(1999) J Biol Chem 274(37): 26209-16.  

4) Khwaja F, D Djakiew, et al (2004) Cancer Res 64(17): 6207-13. 

5) Flores-Torales E,  Cuneo-Pareto S, et al. (2010) Folia Histochem Cytobiol. 48(4):682-6.

6) Kuçi S, Bader P, et al. (2010)  Haematologica. 95(4):651-9.

7) Hermida-Gómez T, Blanco FJ, et al. (2011) Tissue Eng Part A. 17(7-8):1169-79.

8) Jones E, McGonagle D, et al. (2010)  Arthritis Rheum. 62(7):1944-54.

9) Boiko AD, Weissman IL. Et al. (2010) Nature 466(7302):133-7. 

10) Civenni G, Sommer L, et al. (2011) Cancer Res. 71(8):3098-109.

11) Mikami Y, Honda MJ, et al. (2011) Stem Cells Dev. 20(5):901-13.

USD $185.00

In cart: 0
= $185.00
Catalog #: 271-020
Form: Pur/WA
Size: 100 µg
Alternate Name: p75, Nerve Growth Factor Receptor, TNFRSF16
Clone: ANC271/3D7
Applications: FC, EIA

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