Human Lymphotoxin beta receptor (LTbR, TNFSF3) is a member of the TNF receptor superfamily with similarilty to CD120a(TNFR1) and CD120b(TNFR2). It is a expressed mainly on non lymphoid tissues(1) and appears to have an important role in secondary lymphoid organ development(5). Suppression of LTbR signaling can alleviate autoimmunity(2) or exasperate mycobacterial infection(6). Its ligands include Ltab 2 and LIGHT. In mice, LTbR signaling is important for development and function of HEV(2), Dendritic cells(3), and Mast cells(4).
Molecular Structure: A soluble fusion protein consisting of 10 residual amino acids from murine CD8 alpha leader sequence (KPQAPELRGS), followed by the mature extracellular (192aa) domain of human LTbR (SQPQAVP….PLEPLPP) fused to (233aa) murine IgG2a Fc (EPRGPTI….FSRTPGK). Predicted non glycosylated molecular weight of 48.9 kd.
Transfectant Cell Line: CHO
Functional Application: Recombinant human LTbR-muIg fusion protein binds to recombinant human LIGHT in EIA.
(1)T W Mak, M E Saunders eds. The Immune Response 2006 Elsevier Academic Press p 499.
(2) J L Browning, R.A. Fava, et al. Immunity (2005) 23(5): 539-50.
(3)Y Wang, Y Fu, et al. J Immunol (2005) 175: 6997-7002.
(4)P Stopfer, T Hehlgans, et al. J Immunol (2004) 172: 7459-7465.
(5) Gommermann J, JL Browning, et al, Nat Rev Immunol (2003) 3:642-655.
(6) Spahn TW, T Kucharzik, et al. Infection and Immunity (2005) 73(11): 7077-7088.