Human CD56 is an adhesion molecule from the Ig superfamily which is restricted to NK cells in the immune system.  It is believed that NK cells form a first line of defense against tumor cells and cells infected with bacteria and viruses.

Molecular Structure: A soluble fusion protein consisting of the extracellular  loop domains 1-4  (370aa) of human CD56 (20)LQVDIV….CTASN(389)

fused to murine IgG2a Fc and hinge (232aa), with a predicted monomeric molecular weight of  kd 67.8.

Transfectant Cell Line: CHO

Functional Application: CD56(trn)-muIg fusion protein blocks binding of anti-human CD56 antibody (cat #308-020, but not cat #208-020) to NK cells present in ficoll prepared human PBL.

References:

S.P. Bourne, et al, (1991) J Neuro-Oncol  10: 111-119. T.L. Whiteside and R.B. Herberman (1994) Clinical & Diagnostic Laboratory  Immunology.  H. Spits, et al, (1995) Blood  85: 2654-2670.

USD $300.00

In cart: 0
= $300.00
Catalog #: 522-020
Form: Pur/WA
Size: 25 µg
Alternate Name: NCAM
Applications: EIA

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