Human CD137L (4-1BB Ligand) is a type II transmembrane protein constitutively expressed by monocytes, B cells and neuroblastoma cells (1). Binding of CD137 (4-1BB) to CD137L induces monocyte activation (2).
Molecular Structure: A soluble molecule consisting of the extracellular domain (184aa) of human CD137L fused to the extracellular domain (167aa) of murine CD8 alpha, with a predicted monomeric molecular weight of 38.2 kd.
Transfectant Cell Line: CHO
Functional Application: Human CD137L-muCD8 binds to CD137 and blocks binding of anti-CD137 monoclonal antibody.
References:
1. M.R. Alderson, et al, (1994) Eur J Immunol 24: 2219-2227.
2. J. Langstein, et al, (1998) J Immunol 160: 2488-2494.
