Human CD137 (4-1BB) is expressed on activated T cells within 24-48 hours of activation (3).  CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily (1,2).  CD137 appears to be important for T cell proliferation and survival (4) and induces monocyte activation (5).

Molecular Structure: A soluble 55 kd fusion protein consisting of the extracellular (186aa) domain of human CD137 fused to human IgG1 Fc (4), with a predicted monomeric molecular weight of 44.1 kd.

Transfectant Cell Line: CHO

Functional Application: CD137 Ig fusion protein blocks binding of anti-human CD137 to activated CEM human tumor cells and also binds to CD137 Ligand on Raji cells. 

References:

1.   M.R. Alderson, et al, (1994) Eur J Immunol  24: 2219-2227.

2.   H.J. Gruss, and S.K. Dower, (1995) Blood  85: 3378-3404.

3.   B.A. Garni-Wagner, et al, (1996) Cellular Immunol  169: 91-98.

4.   H. Schwarz, et al, (1996) Blood  87: 2839-2845.

5.   J. Langstein, et al, (1998) J Immunol  160: 2488-2494.

USD $375.00

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Catalog #: 502-040
Form: FITC
Size: 50 tests
Alternate Name: 4-1BB
Applications: FC, EIA

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