Human CD252 (CD134L, OX40 Ligand) is a type II membrane protein with homology to TNF which is expressed on activated B cells and activated endothelial cells.  CD252 binds to CD134(OX40) present on  activated T cells, providing a costimulatory signal (1). This pathway seems to be more effective for costimulation of CD4+ helper T cells than for CD8+ effector T cells (4). Blockade of this interaction in mouse abrogated immunological effects in several models of  inflammation and rejection (5,6,7,8).

Isotype: Murine IgG1 Kappa

Immunogen: Human HUVEC and Recombinant soluble human CD252

Specificity: Antibody ANC10G1 binds to CD252 on the cell surface of HUVEC in Flow cytometry, and blocks binding of recombinant CD134-muIg.

 Functional Application: Antibody ANC10G1 blocks binding of Recombinant CD134 to CD134L on HUVEC.

References:

1) W. R. Godfrey, et al, (1994) J Exp Med 180: 757-763.

2)   L.M. Higgins, et al, (1999) J Immunol 162: 486-493. 

3)  A.D. Weinberg, et al, (1999) J Immunol 162: 1818-1826.

4) V.Y.  Taraban, et al, (2002) Eur J. Immunol. 32: 3617-3627.

5) V. Malmstrom, et al, (2001) J Immunol 166: 6972.

6) C. Nohara, et al, (2001) J Immunol 166: 2108-2115.

7) X. Yuan, et al, (2003) J Immunol 170: 2949-2955.

8) L. Tian, et al, (2002) Transplantation 74(1): 133-138.

9) T Uenotsuchi, M Furue, et al. (2006) Intl Immunol 18(12): 1637-1646.

USD $185.00

In cart: 0
= $185.00
Catalog #: 400-020
Form: Pur/WA
Size: 100 µg
Alternate Name: CD252, OX40 Ligand, gp34, anti-OX40L, anti-OX40 Ligand
Clone: ANC10G1
Applications: FC(9), EIA

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