Human FAS ligand (CD95L) is a 40kd type II membrane protein that induces apoptosis in cells expressing FAS (CD95) (1, 2). FAS ligand is one of the major effectors of CD8+CTL and NK activitity. Loss of FAS ligand leads to lymphoproliferative and autoimmune disease.
Isotype: Murine IgG1
Immunogen: Soluble human FAS Ligand
Specificity: Antibody Alf-2.1a recognizes membrane bound and soluble human FAS ligand
Functional Applications: Antibody Alf2.1a blocks FAS ligand activity
1. T. Takahashi, et al, (1994) Intl Immunol 6: 1567-1574.
2. T. Suda, et al, (1997) J Exp Med 186: 2045-2050.