Human tumor necrosis factor alpha (TNF alpha) is a proinflammatory cytokine expressed mainly by activated monocytes and macrophages.  TNF alpha exerts a key role with regard to pathogenesis of many infectious and inflammatory diseases.

Isotype: Murine IgG1

Immunogen: Recombinant human TNF alpha

Functional Application: Antibody J1D9 neutralizes TNF alpha biological activities (2). It prevents TNF alpha induced apoptosis in Jurkat cells (5).

References:

1.  P. Vassalli, (1992) Annu Rev Immunol  10: 411-452.

2.  P.J. McLaughlin, et al, (1992) Anticancer Res  12: 1243-1246.

3.  M. Pasparakis, et al, (1996) Cytokine and Growth Factor Reviews  7: 223-229.

4.  A. Eigler, et al, (1997) Immunology Today  18: 487-492.

5. Kalli K R, Kaufmann S H, et al. (2003) Molecular Pharmacology 64(6): 1434-1443.

USD $150.00

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= $150.00
Catalog #: 398-020
Form: Pur/WA
Size: 100 µg
Alternate Name: Tumor Necrosis Factorα‘, TNFα
Clone: J1D9
Applications: FC, WB, FX

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