Human CD134 (OX40) (ACT35) is an activation-associated antigen which is predominantly expressed on activated CD4 positive cells.  CD134 antigen is a member of the tumor necrosis factor (TNF) receptor family of molecules and may be involved with regulating T cell-dependent B cell proliferation and differentiation (2).

Isotype: Murine IgG1

Immunogen: Human HUT 102 T cells

Specificity: Antibody BerAct35 recognizes an extracellular epitope of the human CD134 molecule of about 35 kd (1, 3). BerAct35 does not block the interaction between CD134(OX40) and CD252(OX40L). 

Functional Application:  Antibody BerAct35 inhibited perforin mRNA expression in PHA stimulated PBMC (5).

References:

1.  U. Latza, et al, (1994) Eur J Immunol  24: 677-683.

2.  E. Stuber, et al, (1995) Immunity  2: 507-521.

3.  Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 464-465.

4.   Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1157-1160.

5.   Ming Li, Yuanchao Zhang (2005) Cell Mol Immunol 2(6):467-271.

USD $275.00

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= $275.00
Catalog #: 355-040
Form: FITC
Size: 120 tests
Alternate Name: OX40, ACT35, CD134
Clone: BerAct35
Applications: FC, EIA, IHC, FX, WB(1), IP(1)

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