Human CD134 (OX40) (ACT35) is an activation-associated antigen which is predominantly expressed on activated CD4 positive cells. CD134 antigen is a member of the tumor necrosis factor (TNF) receptor family of molecules and may be involved with regulating T cell-dependent B cell proliferation and differentiation (2).
Isotype: Murine IgG1
Immunogen: Human HUT 102 T cells
Specificity: Antibody BerAct35 recognizes an extracellular epitope of the human CD134 molecule of about 35 kd (1, 3). BerAct35 does not block the interaction between CD134(OX40) and CD252(OX40L).
1. U. Latza, et al, (1994) Eur J Immunol 24: 677-683.
2. E. Stuber, et al, (1995) Immunity 2: 507-521.
3. Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 464-465.
4. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1157-1160.