Human CD122 (IL-2 R beta) associates with CD25 (IL-2R alpha) to form a high affinity receptor for IL-2 and is expressed on activated T cells, B cells and monocytes (3).  The cytoplasmic domain of CD122 is involved with signal transduction (2).

Isotype: Murine IgG2a kappa

Immunogen: YT-1 acute human leukemia cells

Specificity: Antibody 9A2 is specific for the 75 kd b subunit CD122 of the human high affinity interleukin-2 receptor.

Functional Application: Antibody 9A2 (DU-2) inhibits binding of IL-2 to IL-2R beta (CD122) (1).

References:

1.  M.R. Fung, et al, (1991) J Immunol  147: 1253-1260.

2.  M.A. Goldsmith, et al, (1994) J Biol Chem  269: 14698-14704.

3.  Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1858.

4. Yamaoka K, T Hiroi, et al.(May 2012) Genes to Cells 17: 611-618.  DOI: 10.1111/j.1365-2443.2012.01610.x

USD $150.00

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= $150.00
Catalog #: 343-820
Form: Pur/PF
Size: 100 µg
Alternate Name: IL-2Rβ
Clone: 9A2
Applications: FC

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