Human CD105 (endoglin) is a homodimeric membrane glycoprotein (1) virtually restricted to endothelial cells, and present on some leukemia cells and minor subsets of bone marrow cells.  CD105 binds to TGF-b1 and b3 with high affinity (4).

Isotype: Murine IgG1 kappa

Immunogen: Membrane preparation of human B-lineage leukemia cells

Specificity: Antibody SN6 recognizes an extracellular epitope of the human CD105 homodimer with a molecular weight of about 160 kd. It has been reported to cross react with non human Primate as well as Equine and Porcine(11) CD105.

Functional Application: Antibody SN6 will augment binding of TGF-b1 to CD105 expressing leukemia cells.  Antibody SN6 has been used to identify mesenchymal progenitor cells populations (8,9,10).

References:

1.  Y. Haruta & B.K. Seon, (1986) Proc Natl Acad Sci USA  83: 7898-7902.

2.  H. Hara, et al, (1988) Cancer Res  48: 4673-4680.

3.  W.C. Biddle, et al, (1989) Leukemia Res  13: 699-707.

4.  S. Cheifetz, et al, (1992) J Biol Chem  267: 19027-19030.

5.  B.K. Seon, et al, (1995) Proc Am Assoc Can Res  36: 23.

6.  Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1756-1761, 1762-1764.

7.  B.K. Seon, et al, (1996) Tissue Antigens  48: 417.

8.  S Alsalameh, M Lotz, et al. (2004) Arthritis & Rhematism 50(5): 1522-1532.

9. A Banas, T Ochiya, et al. (2007) Hepatology 46: 219-228.

10. R Williams, HE McCathy, et al. (2010) PLoS ONE 5(10): e13246  doi:10.1371.

11. G Vilahur, L Badimon, et al. Oct 13, 2014 Toxicol Pathol pii: 0192623314551971.

12.  M Vigano,  de Girolamo, et al. (Feb 2017) J Exp Orthopaedics 4: 8.

USD $250.00

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Catalog #: 326-050
Form: R-PE
Size: 120 tests
Alternate Name: Endoglin
Clone: SN6/N1-3A1
Applications: FC(12), IHC

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