Human CD105 (endoglin) is a homodimeric membrane glycoprotein (1) virtually restricted to endothelial cells, and present on some leukemia cells and minor subsets of bone marrow cells. CD105 binds to TGF-b1 and b3 with high affinity (4).
Isotype: Murine IgG1 kappa
Immunogen: Membrane preparation of human B-lineage leukemia cells
Specificity: Antibody SN6 recognizes an extracellular epitope of the CD105 homodimer with a molecular weight of about 160 kd.
Functional Application: Antibody SN6 will augment binding of TGF-b1 to CD105 expressing leukemia cells.
References:
1. Y. Haruta & B.K. Seon, (1986) Proc Natl Acad Sci USA 83: 7898-7902.
2. H. Hara, et al, (1988) Cancer Res 48: 4673-4680.
3. W.C. Biddle, et al, (1989) Leukemia Res 13: 699-707.
4. S. Cheifetz, et al, (1992) J Biol Chem 267: 19027-19030.
5. B.K. Seon, et al, (1995) Proc Am Assoc Can Res 36: 23.
6. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1756-1761, 1762-1764.
7. B.K. Seon, et al, (1996) Tissue Antigens 48: 417.
