The inducible costimulator CD278 (ICOS) is similar to human CD28 (24% homology), and plays an analogous role in the T cell activation process. Unlike CD28, CD278 is only expressed on activated T cells. Secondary signaling through CD28 or CD278  results in discrete cytokine secretion profiles by the activated T cells(1).  Engagement of CD152 (CTLA-4) anergizes cells costimulated with either CD28 and CD278(2). Signaling through CD278 is particularly important in progression of  TH2 immune response (5). The receptor for human CD278(ICOS) is CD275(GL50,ICOS L), a member of the B7 family sharing ~20% homology with CD80 (B7-1) and CD86 (B7-2)(3). Two RNA splice variants exist for this molecule, differing only in the cytoplasmic domain(4).  Blockade of the CD278-CD275 interaction in mice improves allograft survival(6) and reduces EAE(7). 

Isotype: Murine IgG1 Kappa

Immunogen: Human Raji cells, recombinant human CD275-muIg

Specificity: Antibody ANC4E3 binds to recombinant CD275 in EIA.  It does not block the interaction between recombinant CD278 and CD275.

References:

1)  Beier, K.C., R.A. Kroczek, et al. 2000, Eur J Immunol. 30(12):3707-3717.

2)   Riley, J.L., C.H. June, et al. 2001, J. Immunol. 166: 4943-4948.

3)   Ling, V., M. Collins, et al. 2000, J. Immunol. 164: 1653-1657.

4)   Ling, V., M. Collins, et al. 2001, J. Immunol. 166: 7300-7308.

5)   K.C. Beier, et al, (2000) Eur J Immunol 30: 3707-3717.

6)   E. Ozkaynak, et al, (2001) Nat Immunol 2: 591-596.

7)   J.B. Rottman, et al, (2001) Nat Immunol 2: 605-611.

USD $185.00

In cart: 0
= $185.00
Catalog #: 263-820
Form: Pur/PF
Size: 100 µg
Alternate Name: ICOSL, GL50, B7-H2
Clone: ANC4E3
Applications: EIA

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