Human CD40 is a member of the tumor necrosis factor (TNF) receptor family and is present on all B cells except plasma cells. CD40 is also found on some epithelial cells, carcinomas and lymphoid dendritic cells. CD40 plays an important role in B cell activation and the interaction with its ligand CD154 (CD40 Ligand) is essential for isotype switching (3).
Isotype: Murine IgG1
Immunogen: Murine L cells transfectants expressing human CD40
Specificity: Antibody BE-1 recognizes the CD40 molecule of about 44 kd (1, 2).
Functional Application: Binding of cross linked BE-1 will partially activate B cells.
1. C.L. Law, B. Wormann & T.W. LeBien, (1990) Leukemia 4: 732-738.
2. Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 90-91.
3. T.A. Foy, et al, (1996) Annu Rev Immunol 14:591-617.
4. M.R. Kuhné , et al, (1997) J Exp Med 186:337-342.