Human CD27 is a lymphocyte specific member of the tumor necrosis factor (TNF) receptor family and is found primarily on peripheral blood T cells and on a subpopulation of B cells and NK cells.  The ligand for CD27 is CD70, which is a member of the TNF ligand superfamily (2, 3).  Antibody M-T271 does not block the interaction between CD27 and CD70.

Isotype: Murine IgG1

Immunogen: T cell line (from patient with CLL)

Specificity:  Antibody M-T271 recognizes the dimeric CD27 molecule of approximately 110 kd (1, 4) but does not block the interaction between CD70 and CD27.  Clone M-T271 has been shown to abrogate IL-4 production(7) or induce apoptosis(6) in  MLR . Clone M-T271 is crossreactive with cynomolgus monkey CD27 (8).

References:

1.  Leukocyte Typing IV  (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 350-352.

2.  K. Agematsu, et al, (1994) J Immunol  153: 1421-1429.

3.  R.Q. Hintzen, et al, (1994) Immunol Today  15: 307-311.

4.  Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 356-360, 435-437.

5.  K. Agematsu, et al, (1995) J Immunol   154: 3627-3635.

6.  Wischhusen J, M Weller, et al. (2002) Cancer Res 62: 2592-2599

7.  Palmer DR, U Krzych. Eur J Immunol 32(3): 652-661.

8. Yoshino N, Honda M, et al. (2000) Exp Anim 49(2):97-110.

USD $185.00

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= $185.00
Catalog #: 176-040
Form: FITC
Size: 120 tests
Alternate Name: T14
Clone: M-T271
Applications: FC, EIA

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