Expression of human CD25 (the alpha subunit of the IL-2 receptor complex) is dramatically upregulated on activated T cells, B cells, NK cells and macrophages (3).  Antibodies to CD25 are being studied for potential use as an immunodirected therapy to selectively attack (kill) CD25 expressing cells (4).

Isotype: Murine IgG2a

Immunogen: Stimulated PBMC

Specificity: Antibody  7G7B6 recognizes epitope B of the IL-2 alpha receptor of about 55 kd (1,6).

Functional  Application: Antibody 7G7B6 does not block IL-2 binding to its receptor (1).

References:

1.   L.A. Rubin, et al, (1985)  Hybridoma  4:91-102.

2.   B. Boutin, et al, (1989) Neuropediatrics  20: 202-206.

3.   T.A. Waldmann, et al, (1989) Annu Rev Biochem  58: 875-911.

4.   T.A. Waldmann, et al, (1995) Blood  86: 4063-4075.

5.   U.S. Patent No. 4,707,443.

6.   Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 403-406.

USD $300.00

In cart: 0
= $300.00
Catalog #: 174-060
Form: APC
Size: 120 tests
Alternate Name: IL-2R α, TAC, p55
Clone: 7G7B6
Applications: FC, IHC(2)

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