Human CD14 is strongly expressed on myelomonocyte lineage cells including monocytes, macrophages, and a subset of granulocytes.  CD14 is a high affinity receptor for complexes of lipopolysaccharide and lipopolysaccharide binding protein.  A soluble form of CD14 also binds to LPS and LBP (5). 

Isotype: Murine IgG2a

Immunogen: Human thymocytes/Sezary T cells

Specificity: Antibody UCHM1 recognizes an extracellular epiotpe of the human CD14 molecule of about 53 kd.  UCHM1 will also  immunoprecipitate a soluble form of CD14 (1, 2, 3).  It is crossreactive with cynomolgus monkey CD14 (6).

References:

1.  N. Hogg, et al, (1984) Immunology  53: 753-767.

2.  M.O. Labeta, et al, (1993) Eur J Immunol  23: 2144-2151.

3.  Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989)”Reference Antibody”.

4.  Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995)  p. 778-788.

5.  S.D. Wright, (1995) J Immunol  155: 6-8.

6. Yoshino N, Honda M, et al. (2000) Exp Anim 49(2):97-110.

USD $150.00

In cart: 0
= $150.00
Catalog #: 163-020
Form: Pur/WA
Size: 100 µg
Alternate Name: LPS-R
Clone: UCHM1
Applications: FC

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