Human CD10 is a well known marker for common acute lymphoblastic leukemia antigen (CALLA) (4).  CD10 is expressed on normal early B cells in bone marrow and is also on fetal thymocytes.  CD10 expression is lost as the T and B lineage cells mature and only appears again on activated germinal center B cells.  CD10 is present on neutrophils.  CD10 is a neutral endopeptidase and hydrolyzes peptide bonds on the amino side of hydrophobic amino acids.

Isotype: Murine IgG1kappa

Immunogen: Membrane preparation of human B-lineage leukemia cells

Specificity: Antibody SN5c recognizes an extracellular epitope of the the human 100 kd membrane-associated peptidase CD10 (1, 2, 3).

References:

1.  H. Matsuzaki, et al, (1987) Cancer Research  47: 2160-2166.

2.  W.C. Biddle, et al, (1989) Leukemia Research  13: 699-707.

3.  H. Hara, et al, (1988) Cancer Research  48: 4673-4680.

4. Leukocyte Typing V (S.F. Schlossman, et al, eds.)  Oxford University Press, Oxford, (1995)  p. 505-507.

USD $185.00

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= $185.00
Catalog #: 157-030
Form: Biotin
Size: 100 µg
Alternate Name: CALLA, gp100, NEP, MME, Membrane metallo-endopeptidase,
Clone: SN5c/L4-1A1
Applications: FC, WB

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