Ancell Corporation http://www.ancell.com/Array Ancell Corporation Wed, 22 Feb 2012 13:12:52 -0600 http://room34.com/ en hourly 1 SLAM receptors infulence TH17 Differentialtion in SLE http://www.ancell.com/posts//11 http://www.ancell.com/posts//11#comments Fri, 03 Feb 2012 00:00:00 -0600 Ancell Corporation http://www.ancell.com/posts//11  Increased Expression of CD229(SLAMF3) and CD352(SLAMF6)

 in SLE T Lymphocytes Promotes Th17 Differentiation

Chatterjee M., G.C. Tsokos, et al. (2012) J Immunol 188: 1206-1212.

]]>  Increased Expression of CD229(SLAMF3) and CD352(SLAMF6)

 in SLE T Lymphocytes Promotes Th17 Differentiation

Chatterjee M., G.C. Tsokos, et al. (2012) J Immunol 188: 1206-1212.

]]> http://www.ancell.com/posts/rss.xml/11 0 Killer Islet Cells! http://www.ancell.com/posts//10 http://www.ancell.com/posts//10#comments Tue, 06 Dec 2011 00:00:00 -0600 Ancell Corporation http://www.ancell.com/posts//10 Transplanted islet cells were biochemically modified to protect their own long term engraftment in a mouse pancreas.  These cells have the super-ability to cause apoptosis to occur in the infiltrating pathogenic T cells.  This is a novel approach to diabetes treatment! 

”Pancreatic Islets Engineered with SA-FasL Protein Establish Robust Localized Tolerance by Inducing Regulatory T Cells in Mice” E.S. Yolcu, H. Shirwan, et al. (2011) J Immunol 187: 5901-5909

]]> Transplanted islet cells were biochemically modified to protect their own long term engraftment in a mouse pancreas.  These cells have the super-ability to cause apoptosis to occur in the infiltrating pathogenic T cells.  This is a novel approach to diabetes treatment! 

”Pancreatic Islets Engineered with SA-FasL Protein Establish Robust Localized Tolerance by Inducing Regulatory T Cells in Mice” E.S. Yolcu, H. Shirwan, et al. (2011) J Immunol 187: 5901-5909

]]> http://www.ancell.com/posts/rss.xml/10 0 CD30-CD153 and CD134(OX40)-CD252 co stimulatory pathways are essential for CD4 dependant autoimmunity http://www.ancell.com/posts//9 http://www.ancell.com/posts//9#comments Tue, 01 Nov 2011 00:00:00 -0500 Ancell Corporation http://www.ancell.com/posts//9 “Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice”  FM Gaspal, PJL Lane, et al. (2011) JEM 208(8): 1579-1584. 

Ancell related products

Blocking anti-human CD30 mAb

Recombinant  human CD134 and CD252 Proteins

Anti-human CD134 and CD252 mAbs

]]> “Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice”  FM Gaspal, PJL Lane, et al. (2011) JEM 208(8): 1579-1584. 

Ancell related products

Blocking anti-human CD30 mAb

Recombinant  human CD134 and CD252 Proteins

Anti-human CD134 and CD252 mAbs

]]> http://www.ancell.com/posts/rss.xml/9 0 Travel Awards for GLIIFCA 2011 http://www.ancell.com/posts//8 http://www.ancell.com/posts//8#comments Thu, 29 Sep 2011 00:00:00 -0500 Ancell Corporation http://www.ancell.com/posts//8 Ancell and Heliocyte are proud to sponsor travel and poster award stipends for Great Lakes International Imaging and Flow Cytometry Association 2011 conference in Oconomowoc, WI!

]]> Ancell and Heliocyte are proud to sponsor travel and poster award stipends for Great Lakes International Imaging and Flow Cytometry Association 2011 conference in Oconomowoc, WI!

]]> http://www.ancell.com/posts/rss.xml/8 0 The need to better understand Treg plasticity and function in the context of autoimmunity http://www.ancell.com/posts//7 http://www.ancell.com/posts//7#comments Mon, 12 Sep 2011 00:00:00 -0500 Ancell Corporation http://www.ancell.com/posts//7 S. Alice Long and Jane H. Buckner “CD4+ FOXP3+ T Regulatory cells in Human Autoimmunity: More than a Numbers Game”

J Immunol (2011) 187:2061-2066

]]> S. Alice Long and Jane H. Buckner “CD4+ FOXP3+ T Regulatory cells in Human Autoimmunity: More than a Numbers Game”

J Immunol (2011) 187:2061-2066

]]> http://www.ancell.com/posts/rss.xml/7 0 CD30 and CD134 receptors are necessary for CD4 dependent autoimmune tissue damage http://www.ancell.com/posts//6 http://www.ancell.com/posts//6#comments Thu, 25 Aug 2011 00:00:00 -0500 Ancell Corporation http://www.ancell.com/posts//6 Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice.  Gaspal F.M., P.J.L Lane, et al. (2011) JEM 208(8): 1579-1584.

 

Ancell Products

anti-human CD30 antibody products

anti-human CD134(OX40) antibody products

anti-human CD252(OX40L) antibody products

Recombinant human CD134(OX40)

Recombinant human CD252(OX40L)

]]> Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice.  Gaspal F.M., P.J.L Lane, et al. (2011) JEM 208(8): 1579-1584.

 

Ancell Products

anti-human CD30 antibody products

anti-human CD134(OX40) antibody products

anti-human CD252(OX40L) antibody products

Recombinant human CD134(OX40)

Recombinant human CD252(OX40L)

]]> http://www.ancell.com/posts/rss.xml/6 0 New anti-Mouse CD4 PE-Cy7 conjugate http://www.ancell.com/posts//5 http://www.ancell.com/posts//5#comments Fri, 05 Aug 2011 00:00:00 -0500 Ancell Corporation http://www.ancell.com/posts//5 New anti-Mouse CD4 PE-Cy7 conjugate available now!

Watch for more PE-Cy7 conjugates available soon.

]]> New anti-Mouse CD4 PE-Cy7 conjugate available now!

Watch for more PE-Cy7 conjugates available soon.

]]> http://www.ancell.com/posts/rss.xml/5 0 Ancell announces partnership with HelioCyte! http://www.ancell.com/posts//4 http://www.ancell.com/posts//4#comments Mon, 23 May 2011 00:00:00 -0500 Ancell Corporation http://www.ancell.com/posts//4 Ancell announces partnership with HelioCyte to provide cutting edge Flow Cytometry products!


Watch for new products designed to simplify and improve your Flow research!

Twitter account:  Heliocyte
]]> Ancell announces partnership with HelioCyte to provide cutting edge Flow Cytometry products!


Watch for new products designed to simplify and improve your Flow research!

Twitter account:  Heliocyte
]]> http://www.ancell.com/posts/rss.xml/4 0 anti-Mouse CD4/DyLight350 conjugate http://www.ancell.com/posts//3 http://www.ancell.com/posts//3#comments Wed, 18 May 2011 00:00:00 -0500 Ancell Corporation http://www.ancell.com/posts//3 Improved multi-color staining of Mouse tissues

Anti-Mouse CD4 (clone GK1.5)/DyLight350*  conjugate now available!

  Catalog #704-350

DyLight350* is excitable by Near-UV laser Amax 353, and emits in the blue range, Emax 432nm.

Look for more DyLight350 conjugates available soon!

]]> Improved multi-color staining of Mouse tissues

Anti-Mouse CD4 (clone GK1.5)/DyLight350*  conjugate now available!

  Catalog #704-350

DyLight350* is excitable by Near-UV laser Amax 353, and emits in the blue range, Emax 432nm.

Look for more DyLight350 conjugates available soon!

]]> http://www.ancell.com/posts/rss.xml/3 0 CD134(OX40) Signaling Mechanism Elucidated http://www.ancell.com/posts//2 http://www.ancell.com/posts//2#comments Wed, 20 Apr 2011 00:00:00 -0500 Ancell Corporation http://www.ancell.com/posts//2 Engagement of CD134(OX40) by its Ligand (CD252) induces an intracellular signaling complex which  includes PKB, and PI3K, and requires TRAF2.

Takanori S, H Choi, M Croft. (2011) J Immunol 186(6):3547-3555.

 

Ancell Products:

Recombinant human CD134-muIg Fusion protein

Recombinant human CD252(OX40)-muCD8

Monoclonal anti-human CD134(OX40)

Monoclonal anti-human CD252(OX40L)

 

]]> Engagement of CD134(OX40) by its Ligand (CD252) induces an intracellular signaling complex which  includes PKB, and PI3K, and requires TRAF2.

Takanori S, H Choi, M Croft. (2011) J Immunol 186(6):3547-3555.

 

Ancell Products:

Recombinant human CD134-muIg Fusion protein

Recombinant human CD252(OX40)-muCD8

Monoclonal anti-human CD134(OX40)

Monoclonal anti-human CD252(OX40L)

 

]]> http://www.ancell.com/posts/rss.xml/2 0 CD28 Superagonist protects against Rheumatoid Arthritis mediated bone destruction http://www.ancell.com/posts//1 http://www.ancell.com/posts//1#comments Wed, 30 Mar 2011 00:00:00 -0500 Ancell Corporation http://www.ancell.com/posts//1 In mice, use of CD28 superagonist has been shown to increase the % of Treg cells, and protect from Rheumatoid Arthritis mediated bone destruction.
Marlo M Zaiss, Jean-Pierre David, et al. (2010) J Immunol 184: 7238-7246.

Ancell anti-CD28 antibody clone ANC28.1/5D10 has been characterized as a superagonist.

This mAb has been found to be capable of stimulating IL-2 production from Jurkat cells without T Cell Receptor engagement.

Cutting Edge: Monovalency of CD28 Maintains the Antigen Dependence of T Cell Costimulatory Responses
Kevin M. Dennehy, Thomas Hünig, et al. The Journal of Immunology, 2006, 176: 5725-5729.

]]> In mice, use of CD28 superagonist has been shown to increase the % of Treg cells, and protect from Rheumatoid Arthritis mediated bone destruction.
Marlo M Zaiss, Jean-Pierre David, et al. (2010) J Immunol 184: 7238-7246.

Ancell anti-CD28 antibody clone ANC28.1/5D10 has been characterized as a superagonist.

This mAb has been found to be capable of stimulating IL-2 production from Jurkat cells without T Cell Receptor engagement.

Cutting Edge: Monovalency of CD28 Maintains the Antigen Dependence of T Cell Costimulatory Responses
Kevin M. Dennehy, Thomas Hünig, et al. The Journal of Immunology, 2006, 176: 5725-5729.

]]> http://www.ancell.com/posts/rss.xml/1 0