Neutrophils enact lysis of antibody opsonized target tumor cells by utilizing the CD11b - CD18 interaction to form a cytotoxic synapse which leads to trogocytosis. This process can be effectively blocked by blockade with either anti-CD11b or anti-CD18 mAbs, but is enhanced when SIRPa – CD47 blockade is employed.
“Neutrophils Kill Antibody Opsonized Cancer Cells by Trogocytosis” Hanke L Matulung, Timo K van den Berg, et al. (June 2018) Cell Reports 23(13): 3946-59. https://doi.org/10.1016/j.celrep.2018.05.082. PMID: 29949776
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