An important anti Cancer mechanism of CD279(PD-1) blockade elucidated

PD-1 Blockade Promotes Epitope Spreading in Anti-cnacer CD8+ T cell Reponses by Preventing Fratricidal Death of Subdominant Clones To Relieve Immunodomination”  Arash Memarnejadian, S M Mansour Haeryfar, et al. (Nov 2017) J Immunol 199(9): 3348-59.  PMID: 28939757


Often over time, an anti-Cancer immune response narrows into a few dominant (high affinity) CD8+ T cell clones.  This Canadian Research group showed that blockading CD279 (PD-1) restored function of a wider array of sub dominant (lower affinity) anti-Cancer CD8+ T cell clones in a mouse in vivo model.


Related Ancell Research Products


anti-human CD279(PD-1) mAb

anti-human CD274 (PD-L1) mAb

anti-human CD273 (PD-L2) mAb

Recombinant human CD279-muIg

Recombinant human CD274-muIg

Recombinant human CD273-muIg