Nanoparticle based Flu vaccine shows promise in pig study

An Ohio research group tested the efficacy of inactivated Swine Influenza virus (SwlV) encapsulated in 200–300 nm diameter PLGA (poly lactic co-glycolic acid) microspheres. Pigs were immunized twice intranasaly.  While control pigs had fever for four days, treated pigs showed no clinical flu symptoms. 

“Biodegradable nanoparticle delivery of inactivated swine influenza virus vaccine provides heterologous cell-mediated immune response in pigs.” Dhakal, Santosh, G J Renukaradhva, et al.  Journal of Controlled Release (2017) 247 (10): 194-205. PMID: 28057521

Ancell Recombinant CD152(CTLA4)-muIg was used to stain porcine APC-expressed CD80 (B7-1) and CD86 (B7-2) in Flow Cytometry.

Recombinant CD152-muIg             cat# 501-020