CD36/PI3Ky pathway identified for VEGF expression by monocytes

CD36 is a scavenger receptor which can bind to various ligands as well as long chain fatty acids.  It plays a role in innate immunity as well as metabolism.  The authors use transport inhibitors, and uptake of 14-C labeled Phosphate diester of alpha-Tocopheryl (Vitamin E ) to implicate the CD36/PI3Ky as an important pathway for monocyte activation and subsequent secretion of Vascular Endothelial Growth Factor(VEGF).


“alpha-Tocopheryl Phosphate Induces VEGF Expression via CD36/PI3Ky in THP-1 Monocytes”  J M Zingg,  A Azzi, M Meydani, J Cell Biochem DOI: 10.1002/jcb.25871 PMID: 28059487


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anti-CD36 mAb and conjugates