CD36/PI3Ky pathway identified for VEGF expression by monocytes
CD36 is a scavenger receptor which can bind to various ligands as well as long chain fatty acids. It plays a role in innate immunity as well as metabolism. The authors use transport inhibitors, and uptake of 14-C labeled Phosphate diester of alpha-Tocopheryl (Vitamin E ) to implicate the CD36/PI3Ky as an important pathway for monocyte activation and subsequent secretion of Vascular Endothelial Growth Factor(VEGF).
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