anti-CD32 F(ab‘)2 blocked receptors on SLE patient-derived stimulated monocytes and reduced proinflammatory cytokine secretion in vitro

Macrophages derived in culture from SLE patients are directed into secreting proinflammatory cytokines by anti-C1q auto antibodies bound to immobilized C1q complement protein. Pre blocking these monocytes with anti-CD32 (FcgRII ) F(ab’)2 reduced cytokine secretion levels significantly.

“Anti-C1q Autoantibodies from Systemic Lupus Erythematosus Patients Induce a Proinflammatory Phenotype in Macrophages.”  Sophia Thanei, Marten Trendelenburg  J Immunology (2016) 196: 2063–2074. PMID: 26829984

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