TALEN gene editing used to restore normal CD154 expression and function in X-HIGM human T cells

Using TALEN(Transcription Activator-Like Effector Nucleases) technology, these researchers from Seattle Children’s Research succeeded in restoring copies of CD154( CD40L) gene with 3’ UTR under control of its endogenous promoter in human T cells from a patient with X-Linked Hyper-IgM Syndrome (X-HIGM).

“Targeted gene editing restores regulated CD40L expression and function in X-HIGM T cells.” N Hubbard, TR Torgeson, et al. (Feb 2016) Blood [EPub ahead of print] PMID: 26903548

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