Oxidized Mitochondrial products in NETosis are a major component by which LDG drive inflammation in SLE

Neutrophil Extracellular Trap (NET) is a mechanism by which bacteria and other pathogenic organisms are rendered trapped in a site of inflammation.  An activated Neutrophil extrudes it own genomic DNA, rich with histones and other proteins, to trap invading pathogenic organisms.  However, in SLE patients, a distinct subset of Neutrophils, Low Density Granulocytes (LDGs) are prevalent.   NETosis by LDG are a major component of this autoimmune disorder, due to mitochondria and oxidized products in this extrusion.


“Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease.”  C Lood, M J Kaplan, et al. (2015) Nature Medicine 22(2): 146-153. PMID: 26779811



Ancell Low Density Neutrophil Research Products


Human LDG Negative Sorting Mix  (Set of 8 Biotinylated mAbs which bind all cells except LDGs in an RBC-lysed Ficoll prep)


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