anti-human CD252 (CD134L, OX40L)
Human CD134L (OX-40 Ligand) is a type II membrane protein with homology to TNF which is expressed on activated B cells and activated endothelial cells. CD134L binds to CD134 present on activated T cells, providing a costimulatory signal (1). This pathway seems to be more effective for costimulation of CD4+ helper T cells than for CD8+ effector T cells (4). Blockade of this interaction in mouse abrogated immunological effects in several models of immflamation and rejection (5,6,7,8).
mAb name/clone: ANC10G1 Isotype: Murine IgG1k Immunogen:
Specificity: Antibody ANC10G1 binds to CD134L on the cell surface of HUVEC in Flow cytometry, and blocks binding of recombinant CD134-muIg.
Immunochemistry Applications: Flow cytometry EIA Functional Application: Antibody ANC10G1 blocks binding of Recombinant CD134 to CD134L on HUVEC. References:
1) W. R. Godfrey, et al, (1994) J Exp Med 180: 757-763. 2)
L.M. Higgins, et al, (1999) J Immunol 162: 486-493. 3) A.D. Weinberg, et al, (1999) J Immunol 162: 1818-1826. 4) V.Y. Taraban, et al, (2002)
Eur J. Immunol. 32: 3617-3627. 5) V. Malmstrom, et al, (2001) J Immunol 166: 6972. 6) C. Nohara, et al, (2001) J Immunol 166: 2108-2115. 7)
X. Yuan, et al, (2003) J Immunol 170: 2949-2955. 8) L. Tian, et al, (2002) Transplantation 74(1): 133-138.
Catalog Number:400-020 Purified (With Antibiotics)/100ug400-030 Biotinylated/100ug400-040 FITC Conjugate/120 tests400-050 R-PE Conjugate/120 tests