anti-human CD14

Human CD14 is strongly expressed on myelomonocyte lineage cells including monocytes, macrophages, and a subset of granulocytes.  CD14 is a high affinity receptor for complexes of lipopolysaccharide and lipopolysaccharide binding protein.  A soluble form of CD14 also binds to LPS and LBP (5). 

mAb name/Clone: UCHM1

Isotype: Murine IgG2a

Immunogen: Human thymocytes/Sezary T cells

Specificity: Antibody UCHM1 recognizes a membrane bond CD14 molecule of about 53 kd.  UCHM1 will also  immunoprecipitate a soluble form of CD14 (1, 2, 3).

Immunochemistry Applications: Flow cytometry      Immunoprecipitation      Frozen Sections

References:

1.  N. Hogg, et al, (1984) Immunology  53: 753-767.

2.  M.O. Labeta, et al, (1993) Eur J Immunol  23: 2144-2151.

3.  Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989)"Reference Antibody".

4.  Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995)  p. 778-788.

5.  S.D. Wright, (1995) J Immunol  155: 6-8.

Catalog Number:

163-020 Purified (With Antibiotics)/100ug

163-030 Biotinylated/100ug

163-040 FITC Conjugate/120 tests

163-050 R-PE Conjugate/120 tests