Human BAFF(TALL-1, Blys, THANK)-muCD8 Fusion Protein
INFORMATION: The human B cell activating factor (BAFF) and APRIL(a proliferation inducing ligand) are both type II molecules belonging to the TNF superfamily. They are expressed by non-B cells, and are down-regulated by mitogenic stimulation.2 BAFF and APRIL bind to at least two receptors: TACI (transmembrane activator and CAML-interactor) and BCMA (B cell maturation antigen), both of which are restricted to B cells.3,4 Ligation of these receptors with recombinant BAFF dramatically increases IgM production by peripheral blood B cells 1. Cell surface BAFF can be cleaved to form a soluble trimeric molecule.2 BAFF-muCD8 binds to human cell surface TACI/BCMA.
Molecular Structure: A soluble molecule consisting of the extracellular domain (205aa) of human BAFF fused to the extracellular domain (167aa) of murine CD8 alpha, with a predicted monomeric weight of 41 kd.
Transfectant Cell Line:
CHO Immunochemistry Applications:
Flow cytometry Blocking ELISA Functional Application: Human
References: 1) Schneider P., J. Tschopp, et al. J. Exp. Med. 1999, 189(11):1747-1756. 2) Shu, H.B., H. Johnson, W.H. Hui. J Leukoc Biol 1999, 65:680-683. 3) Marsters, S.A., A. Ashkenazi, et al. 2000, Curr Biol 10:785-788. 4) Xia, X., H. Hsu, et al. 2000, J Exp Med, 192(1): 137-143.
Catalog Number: 521-020 Purified (With Antibiotics)/ 25 ug 521-820 Purified (Preservative Free)/ 25 ug
521-030 Biotinylated/ 25ug