anti-human CD80 (B7-1) (IgM isotype)
Human CD80 (B7-1) is a costimulatory ligand for CD28 and CTLA-4. CD80 is expressed on activated B cells (4). mAb name/Clone: BB1 Isotype: Murine IgM
Immunogen: Transformed B lymphoblastoid cells (Baboon) Specificity: Antibody BB1 recognizes the CD80 molecule of 60 kd (1, 6). Immunochemistry Applications:
Flow cytometry Immunoprecipitation Frozen Sections Western Blot Functional Application: Antibody BB1 blocks
adhesion to CD28/CTLA-4, blocks Th induced B cell Ig synthesis and blocks binding of soluble CD152-muIg fusion protein to CD80. References:
1. T. Yokochi, R.D. Holly & E.A. Clark, (1982) J Immunol 128: 823-827. 2. P.S. Linsley, et al, (1990) Proc Natl Acad Sci USA 87: 5031-5035.
3. N.K. Damle, et al, (1991) Eur J Immunol 21: 1277-1282. 4. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 682-684.
5. D. Mauri, et al, (1995) J Immunol 155: 118-127. 6. G.J. Freeman, et al, (1998) J Immunol 161:2708-2715. Catalog Number: