anti-human CD54 (ICAM-1) Domain D2
Human CD54 (ICAM-1) mediates cell adhesion by binding to the integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1). CD54 expression on resting peripheral blood leukocytes is weak
but is upregulated on activated T and B lymphocytes and monocytes. mAb name/Clone: 8.4A6 Isotype: Murine IgG1 Immunogen: Human endothelial cells Specificity: Antibody 8.4A6 recognizes the D2 domain of the CD54 molecule of 90 kd (1, 2). Immunochemistry Applications:
Flow cytometry Immunoprecipitation Frozen Sections Functional Application: Antibody 8.4A6 inhibits CD54 binding to LFA-1.
References: 1. A.R. Berendt, et al, (1992) Cell 68: 71-81. 2. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1548-1550.
3. P.L. Reilly, et al, (1995) J Immunol 155: 529-532. Catalog Number: