anti-human CD178 (CD95L, FAS Ligand)

Human FAS ligand (CD95L) is a 40kd type II membrane protein that induces apoptosis in cells expressing FAS (CD95) (1, 2).  FAS ligand is one of the major effectors of CD8⁺CTL and NK activitity.  Loss of FAS ligand leads to lymphoproliferative and autoimmune disease.

mAb name/clone: Alf-2.1a

Isotype: Murine IgG1

Immunogen: Soluble human FAS Ligand

Specificity: Antibody Alf-2.1a recognizes membrane bound and soluble human FAS ligand

Immunochemistry Applications: Flow cytometry      Immunoprecipitation       Frozen Sections

Functional Applications: Antibody Alf2.1a blocks FAS ligand activity

References:

1.  T. Takahashi, et al, (1994) Intl Immunol  6: 1567-1574.

2.  T. Suda, et al, (1997) J Exp Med  186: 2045-2050.

Catalog Number:

399-020 Purified (With Antibiotics)

399-030 Biotinylated

399-040 FITC Conjugate

399-050 R-PE Conjugate