anti-human CD105 (Endoglin)

Human CD105 (endoglin) is a homodimeric membrane glycoprotein (1) virtually restricted to endothelial cells, and present on some leukemia cells and minor subsets of bone marrow cells.  CD105 binds to TGF-b1 and b3 with high affinity (4).

mAb name/Clone: SN6/N1-3A1

Isotype: Murine IgG1 kappa

Immunogen: Membrane preparation of human B-lineage leukemia cells

Specificity: Antibody SN6 recognizes a CD105 homodimer with a molecular weight of about 160 kd.

Immunochemistry Applications: Flow cytometry      Immunoprecipitation      Frozen Sections (7)

Functional Application: Antibody SN6 will augment binding of TGF-b1 to CD105 expressing leukemia cells.

References:

1.  Y. Haruta & B.K. Seon, (1986) Proc Natl Acad Sci USA  83: 7898-7902.

2.  H. Hara, et al, (1988) Cancer Res  48: 4673-4680.

3.  W.C. Biddle, et al, (1989) Leukemia Res  13: 699-707.

4.  S. Cheifetz, et al, (1992) J Biol Chem  267: 19027-19030.

5.  B.K. Seon, et al, (1995) Proc Am Assoc Can Res  36: 23.

6.  Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1756-1761, 1762-1764.

7.  B.K. Seon, et al, (1996) Tissue Antigens  48: 417.

Catalog Number:

326-020 Purified (With Antibiotics)/100ug

326-030 Biotinylated/100ug

326-040 FITC Conjugate/120 tests

326-050 R-PE Conjugate/120 tests