anti-human CD104 (beta 4 Integrin)

Human CD104 (beta 4 integrin) associates with the alpha 6 integrin chain and binds to laminin and epiligrin and likely has cell-cell adhesion functions.  CD104 is involved in signal transduction (4).

mAb name/Clone: UMA9

Isotype: Murine IgG2a

Immunogen: UM-SCC-1, human squamous cell carcinoma

Specificity: Antibody UMA9 recognizes the CD104 molecule of about 205 kd (1, 3).

Immunochemistry Applications: Flow cytometry      Immunoprecipitation      Frozen Sections     Western Blot

Functional Application: Partially blocks laminin binding.

References:

1.  K.A. Kimmel & T.E. Carey, (1986) Cancer Res  46: 3614-3623.

2.  C VanWaes, et al, (1991) Cancer Res  51: 2395-2402.

3.  Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1655-1663, 1667-1668.

4.  F. Mainiero, et al, (1995) EMBO J  14: 4470-4481.

Catalog Number:

325-020 Purified (With Antibiotics)/100ug

325-030 Biotinylated/100ug

325-040 FITC Conjugate/120 tests

325-050 R-PE Conjugate/120 tests